John S. Lowengrub

540H Rowland Hall University of California Irvine Irvine, CA 92697 (949) 824-8456
Chancellor's Professor of Mathematics
Professor of Biomedical Engineering
Professor of Chemical Engineering & Materials Science

B.A., Cornell University, 1985, Mathematics

Ph.D., Courant Institute of Mathematical Sciences, 1988, Applied Mathematics

Biography and Research: 

Dr. Lowengrub has pioneered the development of mathematical models, applied analysis and numerical methods for problems in fluid dynamics, materials science, and mathematical medicine and biology. In the life sciences, he is best known for his work on multiscale modeling of cancer. Along with his collaborators, Dr. Lowengrub performed the first nonlinear simulations of the partial differential equations governing tumor growth.

His recent research focuses on elucidating the role of cancer stem cells on tumor initiation, progression and metastasis, on the interactions of tumor cells with the host microenvironment, on metabolic abnormalities and heterogeneity in tumors, and on the design of optimal treatment strategies. Working with experimental collaborators, Dr. Lowengrub has tested and validated predictions of the mathematical models and has used the models to reveal underlying biological mechanisms hidden in the experimental data. He is a co-leader of the Systems, Pathways and Targets  Program at the Chao Comprehensive Cancer Center at UCI and the founding director of the Interdisciplinary Graduate Program in Mathematical, Computational and Systems Biology. In the School of Physical Sciences he served as Chair of the Department of Mathematics as well as its Vice Chair for Graduate Studies. Among his many accolades, Dr. Lowengrub received the Francois Frenkiel award from the American Physical Society, a UCI Distinguished MidCareer Award for Research, and the 2014 Julian Cole Lectureship by the Society for Industrial and Applied Mathematics. Outside of the office, Dr. Lowengrub enjoys parenting his six children, five of whom are competitive swimmers. He also likes swimming, running and playing in the surf.

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