OpenChemistry Lecture Videos

Professor James Nowick

CHEM 125: Advanced Organic Chemistry

The course builds upon the concepts and skills learned in a typical yearlong sophomore-level organic chemistry class. Topics include: The Chemical Literature and Databases; Stereochemistry and Structural Organic Chemistry; Synthetic Organic Chemistry; Mechanistic and Physical Organic Chemistry; NMR Spectroscopy. 

 
 
 
 
 
 
 
 
 
 
 
Lecture 7. Chapter 4. Organic Reaction Mechanisms

Lecture 8. Chapter 4. Reaction Kinetics

Lecture 9. Chapter 4. Effect of Activation Energies and Temperature on Reaction Rates: The Eyring Equation

Lecture 10. Chapter 4. Linear Free-Energy Relationships. The Kinetic Isotope Effect

Lecture 11. Chapter 5. Molecular Orbitals and Aromaticity

Lecture 12. Chapter 5. Introduction to Pericyclic Reactions. Electrocyclic Reactions

Lecture 13. Chapter 5. Pericyclic Reactions: Cycloadditions and Sigmatropic Rearrangments

Lecture 14. Chapter 6. Functional Group Transformations, Part 1. The Importance of Oxidation State

Lecture 15. Chapter 6. Functional Group Transformations, Part 2. Oxidation and Reduction of Alcohols and Carbonyl Compounds

Lecture 16. Chapter 6. Functional Group Transformations, Part 3. Some Stereochemically and Mechanistically Interesting Reactions: Stereoselective Reduction; Mitsunobu Reaction; Barton-McCombie Deoxygenation

Lecture 17. Chapter 7. Carbon-Carbon Bond Forming Reactions, Part 1. The Importance of the Carbonyl Group

Lecture 18. Chapter 7. Carbon-Carbon Bond Forming Reactions, Part 2. Claisen Condensation and Michael Addition

Lecture 19. Chapter 7. Carbon-Carbon Bond Forming Reactions, Part 3. Acid-Catalyzed Aldol Reactions and the Mannich Reaction

Lecture 20. Chapter 7. Carbon-Carbon Bond Forming Reactions, Part 4. Enamines, the Wittig Reaction, and Cyclopropanation

Lecture 21. Chapter 8. Concepts in Multistep Synthesis. Umpolung: Benzoin Condensation, Acyl Anion Equivalents, and the Acyloin Condensation

Lecture 22. Chapter 8. Concepts in Multistep Synthesis. Retrosynthetic Analysis. The Diels-Alder Reaction and the Robinson Annulation

Lecture 23. Chapter 9. Physical Influences on Reactions. Effects of Concentration, Stoichiometry, and Other Reaction Conditions

Lecture 24. Chapter 9. Physical Influences on Reactions, continued. Effects of Temperature, Phase-Transfer Catalysis, Ring Size, Solid-Supported Reactions and Reagents

Lecture 25. Chapter 10. Organic Spectroscopy. NMR Spectroscopy: How NMR Works. Chemical Shifts